Magnetic Resonance MicroImaging of cell migration in porous biomaterial scaffolds designed for tissue engineering
نویسندگان
چکیده
Purpose/Introduction Tissue engineering aims to regenerate new biological tissues in order to replace diseased or injured tissues. Polymeric scaffolds for cell seeding, cell growth and proliferation are often extremely sensitive to histological processing. Therefore 3D non-invasive and quantitative imaging methods are needed to study tissue-engineered constructs before and after implantation. This work investigates the use of high resolution MRI as a tool to monitor labeled cell distribution and migration within a porous scaffold.
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Label-free magnetic resonance imaging to locate live cells in three-dimensional porous scaffolds.
Porous scaffolds are widely tested materials used for various purposes in tissue engineering. A critical feature of a porous scaffold is its ability to allow cell migration and growth on its inner surface. Up to now, there has not been a method to locate live cells deep inside a material, or in an entire structure, using real-time imaging and a non-destructive technique. Herein, we seek to demo...
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